产品货号：
Z26499
中文名称：
SHC/SHC1抗体
英文名称：
Anti-SHC/SHC1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SHC/SHC1 Antibody |
| 指标别名 | SH2 domain protein C1;SHC;SHC transforming protein 1;SHC transforming protein 3;SHC transforming protein A;SHC1;SHCA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC |
| 基因名称 | SHC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human SHC(424-440aa DPSYVNVQNLDKARQAV),different from the related rat and mouse sequences by two amino acids. |
| 实际分子量 | 46KD/52KD/66KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SHC1(SHC-transforming protein 1),also known as SHCA,is a protein that in humans is encoded by the SHC1 gene.SCOP classifies the 3D structure as belonging to the SH2 domain family.By Southern analysis of somatic cell hybrids followed by both isotopic and fluorescence in situ hybridization,Huebner et al.(1994) assigned the SHC1 gene to 1q21.Yulug et al.(1995) used fluorescence in situ hybridization to map the SHC1 gene to 1q21.By the same method,an SHC-related sequence(SHCL1) was mapped to 17q21-q22.By FISH analysis and direct sequencing of vectorette library PCR products,Harun et al.(1997) identified SHC1P1,a 3.2-kb processed pseudogene,in Xq12-q13.1.SHC1P1 is 85% identical to mouse Shc p66.Reporter assays showed FKHRL1 transactivates CAT,suggesting a capacity to augment antioxidant scavenging.Nemoto and Finkel(2002) concluded that there is an important functional relationship between forkhead proteins(e.g.,FKHRL1),SHC1,and intracellular oxidants,all of which are though to be involved in the aging process in worms and mammals. |
| Uniprot ID | P29353 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | SHC(Src homology 2 domain containing) transforming protein 1 |
| 蛋白名全称 | SHC-transforming protein 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunocytochemistry 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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